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International Institute for Integrative Sleep medicine (WPI-IIIS)

Tokuyama Laboratory

University of Tsukuba

We measure 24-hour energy metabolism of human subjects using the human calorimeter. Last 15 years of our efforts revealed that 1) rate of substrate oxidation and energy expenditure differ between sleep stages, 2) the time course of sleeping metabolic rate is not simply the result of prolonged fasting. Energy expenditure and carbohydrate oxidation begin to increase prior to awakening despite a prolonged fasting, 3) time course of sleeping metabolism differ between male and female, suggesting that circadian clock of female during sleep is 1-2 h advanced compared to males. Recent findings show that control mechanisms of energy metabolism and sleep are closely related. We believe that it is important to consider the relationship between sleep and metabolism when evaluating the effects of dieting or new sleeping pills.

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our Projects

Research on energy metabolism during sleep


Sleep deprivation

Light exposure

Gut Microbiome

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스크린샷 2020-06-09 11.02.35.png

Kumpei Tokuyama

Principle Investigator


Insung Park



Simeng Zhang


 다채로운 조류

Yoshiaki Tanaka



Asuka Ishihara



Cui Huiyun


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Major achievements


  • Yoshiaki T, Hitomi O, Momoko K, Akira A, Insung P, Katsuhiko Y, Akihiro A, Chihiro S, Haruka O,Simeng Z, Asuka I, Keigo T, Junichi S, Yoshiharu N, Makoto S, and Kumpei T.
 Effect of a single bout of exercise on clock gene expression in human leukocyte. J Appl Physiol. 2020 Apr 1;128(4):847-854

  • Simeng Z, Yoko S, Makoto S, Haruka O, Akiko U, Yoshiaki T, Asuka I, Haruka H, Katsuhiko Y, Insung P, Jaehoon S, Naomi O, Kumpei T, Changes in sleeping energy metabolism and thermoregulation during menstrual cycle. Physiol Rep. 2020;8: e14353

  • Hitomi O, Momoko K, Yoshiaki T, Katsuhiko Y, Kaito I, Akira A, Insung P, Ken K, Naomi O,Makoto S, and Kumpei T. Effect of skipping breakfast for 6 days on energy metabolism and diurnal rhythm of blood glucose in young healthy Japanese males. Am J Clin Nutr. 2019 Jul 1;110(1):41-52

  • Katsuhiko Y, Kaito I, Hitomi O, Insung P, Kumpei T. Meal rich in rapeseed oil increases 24-h fat oxidation more than meal rich in palm oil. PLoS One. 2018 Jun 14;13(6): e0198858

  • Kaito I, Ryosuke K, Yoshiharu N, Reiko K, Insung P, Masashi K, Hitomi O, Momoko K, Naomi O, Makoto S, Kumpei T. Exercise before breakfast increases 24-h fat oxidation in female subjects. LoS One. 2017 Jul 10;12(7): e0180472

  • Insung P, Ryuji O, Hitomi O, Momoko K, Sayaka H, Masanobu H, Yoshihisa K, Makoto S and Kumpei T. Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system:
a randomised, placebo-controlled, double-blinded cross-over trial. Br J Nutr. 2017 Apr;117(7):979-984. 

  • Kayaba M, Park I, Iwayama K, Seya Y, Ogata H, Yajima K, Satoh M, Tokuyama K. Energy metabolism differs between sleep stages and begins to increase prior to awakening. Metabolism. 2017 Apr; 69:14-23.

  • Hitomi O, Fumi K, Masanobu H, Shigeho T & Kumpei T. A Novel Approach to Calculating the Thermic Effect of Food in a Metabolic Chamber. Physiol Rep. 2016 Feb;4(4): e12717

  • Iwayama K, Kawabuchi R, Park I, Kurihara R, Kobayashi M, Hibi M, Oishi S, Yasunaga K, Ogata H, Nabekura Y, Tokuyama K. Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men. J Appl Physiol (1985).2015 Jan 1;118(1):80-5.

  • Kaito I, Reiko K, Yoshiharu N, Ryosuke K, Insung P, Masashi K, Hitomi O, Momoko K, Makoto S, Kumpei T. Exercise Increases 24-h Fat Oxidation Only When It Is Performed Before Breakfast.BioMedicine. 2015 Oct 30;2(12):2003-9.

  • Yasuo S, Kazuteru N, Hitomi O, Yoshiharu N, Shoichiro N, Kumpei T. Continuous Glucose Monitoring During a 100-km Race: A Case Study in an Elite Ultramarathon Runner. Int J Sports Physiol Perform. 2015 Jan;10(1):124-7.

  • Momoko K, Kaito I, Hitomi O, Yumi S, Ken K, Makoto S, Kumpei T. Erratum To: The Effect of Nocturnal Blue Light Exposure From Light-Emitting Diodes on Wakefulness and Energy Metabolism the Following Morning. Environ Health Prev Med. 2015 Jan;20(1):76-7.

Research Grants

・ The DESCENTE and ISHIMOTO Memorial Foundation. Principal Investigator. Elucidating the effect of exercise on sleep quality improvement: A new approach to the analysis of sleep EEG waves. Grant Number XXXXX (2020-2021). JPY 500,000 / a year

・ The 17th Kao Research Council for the Study of Healthcare Science [ID: A-91012]. Principal Investigator. Sex differences in the regulation of sleeping energy metabolism. Grant Numbers A-91012 (2019-2020). JPY 1,000,000 / a year

・ JSPS Grant-in-Aid for Scientists Research [Early Career: ID: 18K17919]. Principal Investigator.

Exploring of sex difference in sleep: insights from circadian rhythms on the new physiological circuitry.

JSPS KAKENHI Grant Numbers JP18K17919 (2018-2020). JPY 4,160,000 / 3 years


・ Keystone Symposia scholarship on Drivers of Type 2 Diabetes: From Genes to Environment, for USD 1,200. October 7-11, 2018 at Seoul in Korea.

・ 第71回日本栄養・食量学会大会トピックス演題選定. Okinawa, Japan. May 19-21, 2017

「睡眠ステージと睡眠始後の時間経過がエネルギー代謝に及ぼす影響: 睡眠時のエネルギー消費と炭水化物酸化は覚醒前から上昇する」

・ 37th Korea Society for Exercise Nutrition Award for The best Presentation. Seoul, Korea. May 27, 2016「Effects of continuous ingestion of chlorogenic acids on energy metabolism and sleep」

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Contact us

Feel free to contact us if you want to visit our lab or if you need any further information.

1-2 Kasuga, Tsukuba, Ibaraki


제출해주셔서 감사합니다!

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